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Results for "

Progesterone Receptor Agonist

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Isotope-Labeled Compounds

1

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0648
    Medroxyprogesterone
    Maximum Cited Publications
    7 Publications Verification

    17α-Hydroxy-6α-methylProgesterone; U8840

    		 Progesterone Receptor Endocrinology Cancer
    Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .
    Medroxyprogesterone
  • HY-119433
    Asoprisnil

    J867

    		 Progesterone Receptor Endocrinology
    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human .
    Asoprisnil
  • HY-B0648S
    Medroxyprogesterone-d3

    17α-Hydroxy-6α-methylProgesterone-d3; U8840-d3

    		 Progesterone Receptor Endocrinology
    Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
    Medroxyprogesterone-d3
  • HY-119384
    Promegestone

    R-5020; Surgestone

    		 Progesterone Receptor Endocrinology Cancer
    Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research .
    Promegestone
  • HY-105634
    Nomegestrol

    		Progesterone Receptor Endocrinology Cancer
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
    Nomegestrol
  • HY-14234
    Glucocorticoid receptor agonist
    1 Publications Verification

    		 Glucocorticoid Receptor Metabolic Disease Inflammation/Immunology Endocrinology
    Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .
    Glucocorticoid receptor agonist
  • HY-15606
    Tanaproget
    1 Publications Verification

    NSP-989

    		 Progesterone Receptor Endocrinology
    Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
    Tanaproget
  • HY-147220
    Dexamethasone oxetanone

    Dex-Ox

    		 Progesterone Receptor Endocrinology
    Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .
    Dexamethasone oxetanone
  • HY-123352
    ZK 216348

    (+)-ZK 216348

    		 Glucocorticoid Receptor Inflammation/Immunology Endocrinology
    ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects .
    ZK 216348
  • HY-123352A
    (-)-ZK 216348

    		Glucocorticoid Receptor Inflammation/Immunology Endocrinology
    (-)-ZK 216348 is the enantiomer of (+)-ZK 216348 (HY-123352). (+)-ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects .
    (-)-ZK 216348
  • HY-105634A
    Nomegestrol acetate

    		Progesterone Receptor Endocrinology Cancer
    Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies .
    Nomegestrol acetate
  • HY-131547
    Org OD 02-0

    10-Ethenyl-19-norProgesterone

    		 Progesterone Receptor p38 MAPK Endocrinology
    Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary .
    Org OD 02-0
  • HY-B0084
    Dienogest
    1 Publications Verification

    STS 557

    		 Progesterone Receptor Endocrinology
    Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest
  • HY-111302
    Norgestrienone

    		Progesterone Receptor Endocrinology
    Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema .
    Norgestrienone

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